Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development
Abstract Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity.Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome, highlighting the biomedical significance of MYSM1 in the hematopoietic system.We and others characterized Mysm1-knockout mice as a m